News

Aug 19, 2019

A new multicenter study at Columbia University links long-term exposure to air pollution, especially ozone, to development of emphysema, a chronic lung disease. These findings matter since ground-level ozone levels are rising, and the amount of emphysema on CT scans predicts hospitalization from and deaths due to chronic lower respiratory disease.

Aug 19, 2019

The researchers discovered for the first time that Bcl11b, a transcription factor, determines which class of odorant receptor (OR) gene is expressed in olfactory neurons. In the absence of Bcl11b, olfactory neurons are fated to class I. But the fate can be switched to class II in the presence of Bcl11b. This also corroborates the idea that class I OR is the default OR, which undergoes a transcriptional switch in the presence of Bcl11b.

Aug 19, 2019

A new study finds that melanoma brain metastasis occurs when tumor cells "hijack" an inflammatory pathway in the brain. Blocking this pathway could prevent these metastases from developing, according to the research. The scientists utilized a mouse model of spontaneous melanoma brain metastasis to study the interactions of melanoma tumors within the brain microenvironment. They discovered that melanoma brain metastasis is facilitated by the takeover of a physiological inflammatory pathway by astrocytes, the brain cells that maintain a protected environment in the brain.

Journal Abstracts

Aug 16, 2019

The purpose of this study is to propose a selection strategy of joint-sparing operative procedures for humeral malignancies based on tumor origin, site, and bone strength. Alcohol devitalized autograft replantation is applicable for diaphyseal humeral primary malignancies, with a good response to chemotherapy and a low bone strength score (≤10). In situ microwave ablation is suitable for diaphyseal and (or) metaphyseal low-grade malignant bone tumors or metastases with a low bone strength score (≤10). Intercalary prosthetic reconstruction is preferred for diaphyseal metastases with a high bone strength score (> 10).

Aug 16, 2019

The aim of this study was to examine demographic, site, stage, and survival factors in patients with epithelial-myoepithelial carcinoma. Epithelial-myoepithelial carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival.

Aug 16, 2019

The objective of this study is to investigate the role of G-protein coupled receptor 64 (GPR64) in endometrial cancer. To determine a tumor suppressor role of GPR64 in endometrial cancer, they used a siRNA loss of function approach in human endometrial adenocarcinoma cell lines. The results of this study suggest that GPR64 plays an important tumor suppressor role in endometrial cancer.

Recent Articles

Aug 20, 2019

The Eleventh Annual Meeting of the Society for the Neurobiology of Language will be held in Helsinki, Finland from August 20 – 22, 2019. The meeting will convene in the iconic Finlandia Hall, located in the heart of Helsinki. Attendees will appreciate the distinctive atmosphere, functionality, beautiful location in a park by the sea.

Aug 20, 2019

FOB 2019 will focus on the most relevant topics and issues of ophthalmology, both theoretical and practical. You will be able to gain insights, exchange ideas and meet the experts and participants from different countries. This will be an outstanding scientific and educational meeting that will facilitate the spread and exchange of knowledge, skills, and attitudes, between experts, researchers, clinicians, and trainees. The industry exhibition will provide an excellent opportunity to see and test the latest equipment, the newest pharmaceutical developments and therapeutic approaches in ophthalmology. The congress will take place in Radisson Blue Hotel Lietuva, situated on the bank of the River Neris in the center of Vilnius.

Aug 20, 2019

International Conference on Gerontology and Geriatric Medicine 2019 (SilverAge 2019) will create the most outstanding platform to engage in dialogue for and of older persons. SilverAge 2019 invites you to submit your research papers and case studies on or before 27th March 2019. The conference theme is "Well-being in Silver Age – from Individual to Society". However, please note that any abstract which is in line with the conference theme will be considered for review.

Clinical Research

Aug 20, 2019

Patients with AGC who achieved objective response or stable disease after 2-6 months of first-line chemotherapy were randomly assigned to one of two groups, to receive either S-1 (40 mg for BSA<1.25 m2, 50 mg for 1.25≤BSA<1.50 m2 and 60 mg for BSA≥1.50 m2 b.i.d. on days 1-14, q3w) as maintenance therapy or observation. The treatment will continue until disease progression or unacceptable toxicity.

 

Aug 20, 2019

This is a randomized, placebo-controlled, double masked trial of the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction. Dry eye syndrome (DES) is a persistent feeling of ocular discomfort that encompasses dryness, irritation, foreign body sensation and burning. In the United States, it is the most common non-refractive cause of visits to eye care providers, and has been shown to have a significant impact on quality of life of patients who suffer from this condition. most common cause of DES is Meibomian gland disease (MGD). In the vast majority of cases, MGD is not binding, but rather causes persistant ocular discomfort. Oral antibiotics, particularly the tetracyclines and macrolides, are frequently prescribed for the treatment of MGD. There is little good-quality evidence to support this practice. This study is designed to evaluate the effectiveness of oral azithromycin on patient-reported dry eye symptoms. Concomitantly, we will also study the composition of the ocular surface microbiome in MGD, and its response for oral antibiotics.

Aug 20, 2019

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of TA-650 in patients with Behcet's disease ( BD ) with special lesions after the administration of TA-650 at a dosage of 5 mg/kg in weeks 0, 2, and 6, then every 8 weeks after week 14 up to week 46.

Aug 20, 2019

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of TA-650 in patients with Behcet's disease ( BD ) with special lesions after the administration of TA-650 at a dosage of 5 mg/kg in weeks 0, 2, and 6, then every 8 weeks after week 14 up to week 46.

Aug 20, 2019

Vaccines made from a peptide may make the body build an immune response and kill tumor cells. Randomized phase I trial to study the effectiveness of vaccine therapy in treating patients who have metastatic cancer that has not responded to previous therapy.

Aug 12, 2019

Cook Children's Health Care System is conducting an Interventional study in 250 people in order to investigate whether a new investigational drug called Fluorodopa F 18, when used with a PET scan, can find the focal lesion and guide the surgeon to remove it, thus curing the patient and preventing further brain damage.

Aug 12, 2019

Cook Children's Health Care System is conducting an Interventional study in 250 people in order to investigate whether a new investigational drug called Fluorodopa F 18, when used with a PET scan, can find the focal lesion and guide the surgeon to remove it, thus curing the patient and preventing further brain damage.

Publications

Sep 07, 2019

Objective: The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.

Topics

  • Pediatric endocrinology
  • Pediatric diabetes
  • Inherited metabolic diseases

Article formats

Original Research, Reviews, Mini Reviews, Opinion Papers, Case Report, Short Communications, Letters to the Editor (including comments on published papers), Book Reviews.

Aug 20, 2019

The 13th edition of the popular book, Current Surgical Therapy is scheduled to be released in November 2019. It is an ideal resource for written, oral, and recertifying board study, as well as an excellent reference for everyday clinical practice.

Aug 20, 2019

This upcoming publication offers state-of-the-art instruction to clinicians on how to recognize, diagnose and assist children with autism spectrum disorders, from early in life to transition to adulthood, while also exploring how to support pediatric patients by working with families.

Aug 20, 2019

Andreas Meiser summarizes the current literature on inhalation sedation of critically ill patients. To meet clinical demands, he describes the development of new devices to administer volatile anesthetics together with common ICU ventilators. Their basic principle is called anesthetic reflection.

Aug 19, 2019

The 9th edition of Practice Management for the Dental Team includes a wide range of dental office skills which are mapped to the Dental Assisting National Board (DANB) test blueprint including technology, communications, appointment setting, dental charting, business office procedures, etc.

Aug 19, 2019

Navigating Organized Urology, A Practical Guide is a book for researchers and practicing urologists and offers practical guidance for newly qualified urologists transitioning into urological practice.

Aug 14, 2019

Clinical Colorectal Cancer is a peer-reviewed, quarterly journal that publishes original articles describing various aspects of clinical and translational research of gastrointestinal cancers. Clinical Colorectal Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of colorectal, pancreatic, liver, and other gastrointestinal cancers. The main emphasis is on recent scientific developments in all areas related to gastrointestinal cancers.

Videos

Aug 18, 2019

Mike Zervas, CEO of Encompass Healthcare Data Solutions, shares his practice management insights for common problems faced in anesthesia practice management and how to run a streamlined, optimized and profitable practice.

Aug 16, 2019

Watch Dr. Bashar Safar, chief of colorectal surgery, describe one of the latest approaches against advanced stage rectal cancer: the 5x5 protocol. As an aggressive form of rectal cancer treatment, the 5x5 protocol delivers 5 grays (Gy) of radiation to patients for five days for a total of 25 Gy.

Aug 16, 2019

Dr. Sanket Pisat, Consultant, Gynecological Endoscopic Surgeon discuss Laparoscopic Ovarian Cystectomy for Endometrioma.

Aug 16, 2019

This video presents unimanual (one-handed) 27 gauge vitrectomy for tractional retinal detachment surgery. This surgical technique provides completely immobilized retina and minimizes the forces applied onto the retinal surface, eliminates the need for chandelier illumination, reduces the number of entrance and exit of the instruments during the surgery.

Case Studies

Aug 19, 2019

Postdural puncture headache is a leak of cerebrospinal fluid that lowers intracranial pressure and usually presents as a positional headache. If conservative treatments are not successful, the epidural blood patch is the gold standard of the treatment for dural puncture. The interlaminar approach is the most commonly used technique for an epidural blood patch. This case report describes a patient who was treated with a transforaminal epidural blood patch for postdural puncture headache following an acupuncture procedure on his lower back after two epidural blood patches using an interlaminar approach had failed. The patient underwent an acupuncture therapy for management of chronic low back pain due to postlaminectomy syndrome. After the procedure, the patient had a severe headache and the conservative treatment was not effective.

Aug 19, 2019

A 35-year-old male with no prior ophthalmic history presented with headaches, altered mental status, and fever of unknown origin. A lumbar puncture (LP) revealed an elevated white count with lymphocytic predominance, confirming a suspected meningitis. After an extensive work-up, he was discharged on oral acyclovir to cover for presumed aseptic meningitis. The patient initially improved, however, bilateral eye pain, redness, and photophobia 2 weeks after discharge prompted his first visit to the ophthalmology clinic. Exam at that time was consistent with bilateral anterior uveitis for which he was given topical prednisolone and cyclopentolate. In addition to the preceding work-up, quantitative immunoglobulin serology including IgG4 levels was added. At follow-up, he was found to have increased ocular inflammation with vitreitis, nerve head edema, and subclinical macular thickening. Visual acuity (VA) had decreased in both eyes. Serology titers for IgG had resulted in a significant elevation in IgG subclass 4 (IgG4). Optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) confirmed posterior retinal involvement. The patient was diagnosed with presumed bilateral panuveitis secondary to IgG4-ROD.

Aug 19, 2019

This is a case report of a 31-year-old primigravida who was diagnosed with an asymptomatic acute parvovirus B19 infection in the second trimester of pregnancy and its suspected association with an increased nuchal translucency (NT) measurement. Parvovirus B19 is a single-stranded DNA virus that is cytotoxic to erythroid progenitor cells, causing inhibition of erythropoiesis. While maternal disease is usually mild, fetal infection can result in spontaneous abortion, aplastic anemia, nonimmune fetal hydrops, and fetal demise. This fetus had an increased NT of 3.2 mm at 11 weeks' gestation with a normal male karyotype and microarray analysis on chorionic villi sampling, in addition to a normal fetal echocardiogram at 15 weeks' gestation.

Aug 19, 2019

A 36-year-old Iranian man presented to our clinic for evaluation of constitutional symptoms. His past medical history was significant for papillary thyroid carcinoma due to which he had undergone total thyroidectomy, cervical lymph node dissection, and radioactive iodine therapy 14 years ago. Six months prior to admission, he received radioactive iodine therapy due to the metastatic involvement of both lungs with papillary thyroid carcinoma in another center with consequent improvement in symptoms. Diffuse nodular lesions in both lungs, a lesion in the lower lobe of his left lung, not present 6 months ago, peritoneal carcinomatosis, and several para-aortic lymphadenopathies were detected by imaging studies.