News

Dec 06, 2019

A study published online in the journal Health Affairs suggest that people in rural areas of the U.S. who receive subsidies to buy health insurance in the Health Insurance Marketplaces pay less in premiums than their counterparts in urban areas. This change is a result of Trump Administration's 2017 cut of the Affordable Care Act's cost-sharing reduction payments to health insurers.

Dec 06, 2019

New research published by The University of Texas Health Science Center at Houston (UTHealth) suggests high school students with a history of sports-related concussions might be at an increased risk for suicide completion.

Dec 06, 2019

Noise measurements made in real-time at randomly selected multisurgery specialty ORs revealed sound levels comparable to a hairdryer or bulldozer during critical times of surgery on both surgical count and anesthesia emergence. The study authors emphasized that these results provide strong evidence to support more restrictive noise policies in the OR.

Journal Abstracts

Dec 06, 2019

In this study, they have evaluated the efficacy and safety of FOLFIRI maintenance treatment after FOLFIRINOX induction in a retrospective single-center study. Patients with advanced PDA treated with FOLFIRI as maintenance therapy after achieving disease control under FOLFIRINOX according to the local operating procedure between 2011 and 2016 were identified. Medical records of this group were evaluated retrospectively. In the selected group of PDA patients achieving disease control with FOLFIRINOX, FOLFIRI maintenance therapy was feasible, safe, and effective, with some patients achieving long-term disease stabilization.

Dec 04, 2019

Lauren Bowen Reoma MD et al describe the first case of fatal JC virus (JCV) encephalopathy following immunosuppressive treatment that included ruxolitinib. Incorporating next generation sequencing, Sanger sequencing, tissue immunohistochemistry, and formalin-fixed hemisphere 7T magnetic resonance imaging, postmortem analysis was carried out. A new 12bp insertion that changed the transcription site binding pattern in an otherwise “wild-type virus,” which has long been presumed to be the nonpathogenic form of JCV, was revealed by JCV DNA isolated from postmortem tissue samples. The presence of infection in cortical neurons, hippocampal neurons, and glial and endothelial cells was shown by anti-VP1 staining. The findings of this case extend the spectrum of recognized JCV diseases related to broad-spectrum immunosuppression, including JAK-STAT inhibitors, as well as provide information about an additional neurotropic virus strain of the archetype variety.

Dec 04, 2019

Sarah Horton et al ascertained longer-term results of candidates recruited from a single center in the SYCAMORE trial, a randomized placebo-controlled trial of adalimumab vs placebo. For this investigation, they reviewed records of all 28 SYCAMORE candidates selected at the Bristol Eye Hospital at nearly 3-monthly intervals up to 5 years from the trial randomization date. After 1-2 years of treatment, drug-induced remission of JIA-U did not persist when adalimumab was withdrawn. According to this retrospective interventional case series, adalimumab has been well-tolerated and the outcomes of visual acuity have been outstanding.

Recent Articles

Dec 06, 2019

A 76-year-old male with a small bowel neuroendocrine tumor with hepatic metastases presented with new onset lower extremity swelling, bloating, and weight gain which ultimately lead to cardiac magnetic resonance (CMR) to evaluate for cardiac involvement of disease. CMR showed right and left ventricular myocardial metastases along with findings suggestive of carcinoid heart disease. The patient had severe tricuspid valve regurgitation necessitating surgical valve repair. The patient underwent bioprosthetic tricuspid valve replacement and debulking of the metastases with surgical pathology confirming neuroendocrine tumor metastases. Follow-up clinical evaluations at 3, 6, and 9 months postoperatively showed improvement in cardiac function and stable hepatic tumor burden. 

Dec 06, 2019

Craniopharyngiomas remain a challenging pediatric brain tumor. The challenging aspects are not only the technical ones, yet choice of the surgical approach, decision making regarding hormone replacement therapy and choice of radiation (radiotherapy vs intracavitary radiation) are all clinical nuances. No single approach is ideal or complications-free. Treatment should be individualized and tailored according to the patient clinical condition and imaging findings.

 

Dec 06, 2019

A 76-year-old male with a small bowel neuroendocrine tumor with hepatic metastases presented with new onset lower extremity swelling, bloating, and weight gain which ultimately lead to cardiac magnetic resonance (CMR) to evaluate for cardiac involvement of disease. CMR showed right and left ventricular myocardial metastases along with findings suggestive of carcinoid heart disease. The patient had severe tricuspid valve regurgitation necessitating surgical valve repair. The patient underwent bioprosthetic tricuspid valve replacement and debulking of the metastases with surgical pathology confirming neuroendocrine tumor metastases. Follow-up clinical evaluations at 3, 6, and 9 months postoperatively showed improvement in cardiac function and stable hepatic tumor burden. 

Clinical Research

Dec 05, 2019

This is a prospective, two-arm randomized, baseline-controlled, pilot study to evaluate treatment outcome of 3 Vbeam® Prima PDL treatments in subjects applying once-daily RHOFADE® topical oxymetazoline HCL 1.0% cream for improvement in erythematotelangiectatic rosacea. Treatment outcome will be compared to oxymetazoline HCL 1% cream alone. Subjects with moderate or severe (Grade 3 or 4) erythematotelangiectatic rosacea on the validated Clinical Erythema Assessment (CEA) Scale and Subject Self-Assessment (SSA) Scale will be enrolled and randomized to one of two study arms.

Dec 05, 2019

This is an interventional, randomized, double-blind, placebo-controlled study that will be conducted to investigate the effect of a new probiotic strain Lactobacillus salivarius PS7 on Acute Otitis Media (AOM) in children with recurrent AOM history. The study duration will be 7 months, which includes a 6-month product administration and a 1-month follow-up period. Participants will be randomized assigned to one of the three study groups: the control group; a 3 months probiotic +3 months placebo consumption group and a 6 months probiotic consumption group. The efficacy of the probiotic strain to reduce the incidence of AOM episodes will be assessed by counting AOM episodes occurring in study participants, during the entire intervention and follow-up periods, by bilateral comparison of each of the treatment groups with the control group.

Dec 05, 2019

The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with a familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next-generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease will be done. The screening will be performed on affected and unaffected family members, in order to outline new pedigrees that either validate previous findings or constitute novel discoveries.

Dec 05, 2019

The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with a familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next-generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease will be done. The screening will be performed on affected and unaffected family members, in order to outline new pedigrees that either validate previous findings or constitute novel discoveries.

Dec 05, 2019

The purpose of this study is to compare articulating and static antibiotic-impregnated spacers for the treatment of chronic periprosthetic infection complicating total knee arthroplasty through a prospective, randomized clinical trial. The goals of this trial are to determine the effect of spacer design upon eradication of infection, knee function, ease of reimplantation, and range of motion. The investigators hypothesize that articulating spacers will provide shorter operative times at reimplantation while improving knee function and range of motion.

Dec 03, 2019

The purpose of this study is to learn more about the medical problems and the genetic factors involved in a recently defined form of inherited dementia called "familial dementia with neuroserpin inclusion bodies (FDNIB)." Abnormal substances in nerve cells of patients with this disease affect brain and nervous system function, causing confusion, memory decline and impaired cognition (thinking ability). Patients also develop movement disorders and, possibly, seizures. Symptoms begin in midlife, between 45 and 55 years of age.

Patients with FDNIB and family members 18 years of age or older at risk for the disease may be eligible for this 3-year study.

Participants will have a medical and family history and review of medical records; interview with a medical geneticist (specialist in genetics); physical, neurological and psychiatric examinations; and the following tests and procedures:

  1. Blood tests to assess general health
  2. Chest and skull X-rays
  3. Electrocardiogram (EKG)-record of the electrical activity of the heart using electrodes placed on the chest
  4. Electroencephalogram (EEG)-record of the electrical activity of the brain using electrodes placed on the head
  5. Ultrasound of the abdomen-imaging of abdominal organs using sound waves
  6. Brain magnetic resonance imaging (MRI)-imaging of the brain using a strong magnetic field and radio waves
  7. Hearing evaluation
  8. Assessment of performance of daily living activities
  9. Single photon emission computed tomography (SPECT)-imaging of brain metabolism and blood flow using a radioactive substance injected into a vein

The evaluation will be done over a 3- to 4-day period. At their completion, participants will meet with a physician and a genetics counselor to discuss the clinically significant findings. Participants may be asked to return for follow-up evaluations every 6 months to a year (depending on the individual's condition) for 3 years.

Dec 03, 2019

 

Pediatric patients who have undergone surgery for congenital or infantile cataracts have a risk of developing suspected glaucoma and glaucoma, but the current evidence does not address our understanding of the incidence and associated risk factors of suspected glaucoma/glaucoma for application in clinical standard care. Therefore, this study investigated the incidence of and risk factors for suspected glaucoma/glaucoma in patients who have undergone surgery for congenital/infantile cataracts.

Publications

Dec 04, 2019

Journal of Magnetic Resonance in Medicine is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications.

Dec 04, 2019

Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology. The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.

Dec 04, 2019

Journal of Cardiovascular Pharmacology and Therapeutics (JCPT) provides clinical and basic/translational investigators with novel insights into state-of-the-art therapeutic approaches for cardiovascular diseases. JCPT also features commentaries written by respected investigators in the field

Dec 04, 2019

Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to students, clinicians and researchers involved in the broad area of endocrinology and metabolism. This field of medicine and biology is rapidly advancing and a major challenge is to keep abreast of the advances in the field. The mission of this review journal is to keep those interested individuals informed of all the latest exciting advancements that are essential to their research or clinical practice.

Dec 04, 2019

Therapeutic Advances in Gastroenterology is an open access, peer-reviewed journal which focuses in pioneering efforts and innovative studies across all areas of gastroenterology and hepatology. This journal is a member of the Committee on Publication Ethics. 

Dec 02, 2019

Habif's Clinical Dermatology: A Color Guide to Diagnosis and Therapy provides superbly illustrated, easy-to-follow guidance on skin conditions commonly seen in practice. This bestselling manual helps you identify, treat, and manage even hard-to-diagnose skin disorders and provides state-of-the-art answers on every aspect of dermatologic care. In this carefully revised 7th Edition, Dr. James Dinulos builds upon the foundation of excellence established by Dr. Thomas Habif, ensuring that this manual remains a global leader in the field and an indispensable resource in daily practice.

Dec 02, 2019

This guide brings thought leaders and master clinicians together to share their wisdom and expertise regarding clinical decisions surrounding unilateral and bilateral vocal fold paralysis. Designed as a what-to-do and why as opposed to a how-to guide, the authors detail the reasoning process from workup, through intervention, to post-treatment decision making. The text is organized around decision points in the management of vocal fold paralyzes such as decisions in regard to timing, intervention, implants, reinnervation, drugs, voice therapy, and post-operative care.

 

Videos

Dec 06, 2019

 

Watch Dr. Brandon D. Ayres, MD, Cornea Service, Wills Eye Institute talk about INTACS as a good treatment option for Ectasia.

Dec 06, 2019

Dr. Jena Miller, Johns Hopkins Center for Fetal Therapy physician, discusses the results from a recent study on the performance of 2-port open fetoscopy for fetal spina bifida repair in a newly established program.

Dec 06, 2019

 

Watch Dr. Sara Tolaney, MD, MPH, discuss the advances in immunotherapy to treat metastatic breast cancer. Recent trials have tested immunotherapy drugs in tandem with other agents, and early results offer reason for encouragement. One trial found that in patients with metastatic triple-negative breast cancer whose tumor cells carry the PD-L1 receptor, combining an immune checkpoint inhibitor and chemotherapy produced better results than chemotherapy alone, leading to the first FDA approval of an immunotherapy in breast cancer. Outcomes like this have led investigators to explore whether other chemotherapy agents or immunotherapy drugs might make a more effective pairing. Combinations of immunotherapy drugs and other therapies are being tested in other types of breast cancer as well.

Dec 06, 2019

Watch Dr. Armando G. Melani, MD present "Approach to the splenic flexure tumor complete mesocolic excision?" at the "Masters Left Colon: Practicalities, Tips and Tricks".

Case Studies

Dec 06, 2019

A 76-year-old male with a small bowel neuroendocrine tumor with hepatic metastases presented with new onset lower extremity swelling, bloating, and weight gain which ultimately lead to cardiac magnetic resonance (CMR) to evaluate for cardiac involvement of disease. CMR showed right and left ventricular myocardial metastases along with findings suggestive of carcinoid heart disease. The patient had severe tricuspid valve regurgitation necessitating surgical valve repair. The patient underwent bioprosthetic tricuspid valve replacement and debulking of the metastases with surgical pathology confirming neuroendocrine tumor metastases. Follow-up clinical evaluations at 3, 6, and 9 months postoperatively showed improvement in cardiac function and stable hepatic tumor burden. 

Dec 06, 2019

A 76-year-old male with a small bowel neuroendocrine tumor with hepatic metastases presented with new onset lower extremity swelling, bloating, and weight gain which ultimately lead to cardiac magnetic resonance (CMR) to evaluate for cardiac involvement of disease. CMR showed right and left ventricular myocardial metastases along with findings suggestive of carcinoid heart disease. The patient had severe tricuspid valve regurgitation necessitating surgical valve repair. The patient underwent bioprosthetic tricuspid valve replacement and debulking of the metastases with surgical pathology confirming neuroendocrine tumor metastases. Follow-up clinical evaluations at 3, 6, and 9 months postoperatively showed improvement in cardiac function and stable hepatic tumor burden. 

Dec 06, 2019

This case is about a 35-year-old male with no past medical history who presented with rhabdomyolysis due to newly diagnosed hypothyroidism without any precipitating factors and was treated successfully with intravenous fluids and levothyroxine.

Dec 06, 2019

A 25 year-old-man with HIV came to the emergency room (ER) with complaints of intermittent rectal bleeding for two months. His CD4 count was less than 20 cells/µL. He was MSM (men having sex with men) and has receptive anal intercourse with men. His stool work-up was unrevealing for infectious etiology. Swabs for gonorrhea and chlamydia were negative. Colonoscopy revealed erythematous, congested, friable rectal mucosa with two superficial ulcers. Biopsies of the ulcer were positive for acid fast staining bacteria and the culture grew MAI. His blood culture was negative for growth of acid-fast bacteria (AFB).