News

Mar 18, 2019

The U.S. FDA said it approved expanded the use of Regeneron Pharmaceuticals Inc and Sanofi SA’s eczema drug Dupixent to include patients aged between 12 and 17. This drug targets two key proteins that may play a central role in the inflammation underlying certain allergic diseases. The drug represents an important growth driver for both the companies which are testing its use in patients with conditions like eosinophilic esophagitis as well as food and environmental allergies.

Mar 15, 2019

A new proposal seeks to ban providers and insurers from balance billing patients for unanticipated out-of-network care or medical bills. This is going to help states who have implemented an acceptable process for addressing out-of-network reimbursement to take superiority over the new federal law.

Mar 14, 2019

Researchers at the University of New Hampshire have created a hydrogel that could one day be made into a contact lens to more effectively treat corneal melting, a condition that is a significant cause for blindness worldwide.

Journal Abstracts

Mar 15, 2019

This was a retrospective study where they evaluated LAG-3 and TIGIT protein expression patterns and correlation with programmed death-1 (PD-1) expression and determined their effects on clinicopathological characteristics and biological responses in melanoma. Results suggest expression of LAG-3 and TIGIT represents an independent unfavorable prognostic factor in cutaneous melanoma.

Mar 15, 2019

This is a retrospective study to evaluate the early PD-1 therapy discontinuation in responding to metastatic cancer patients. The results of the current study suggest that patients whose PD-1 therapy has been discontinued in response can have a long IO therapy-free period without the need for the next line of therapy.


 

Mar 13, 2019

Anca Ciobanu, MD et al studied 15,247 pregnancies from 2 maternity hospitals in England in this prospective observational study, to compare the performance of screening for delivery with preeclampsia at ≤2 and ≤4 weeks after assessment at 35+0–36+6 weeks gestation between the use of percentile cut-offs in placental growth factor alone or the soluble fms-like tyrosine kinase-1/placental growth factor ratio and the competing risks model. They identified 326 pregnancies (2.1%) that subsequently experienced preeclampsia. Outcomes revealed the superior performance of screening for imminent delivery with preeclampsia by the competing risks model when compared to that of placental growth factor alone or the soluble fms-like tyrosine kinase-1/placental growth factor ratio at 35+0–36+6 weeks gestation.

Recent Articles

Mar 18, 2019

The 25th World Cardiology Conference is scheduled to be conducted between July 10-11, 2019 and is to be held in Osaka, Japan. The theme for this year's conference is 'New Insights in Cardiology for a diverse World'. The conference consists of multiple scientific sessions and renowned speakers who will be presenting their talks on current updates in the field of Cardiology. 

Mar 18, 2019

The U.S. FDA said it approved expanded the use of Regeneron Pharmaceuticals Inc and Sanofi SA’s eczema drug Dupixent to include patients aged between 12 and 17. This drug targets two key proteins that may play a central role in the inflammation underlying certain allergic diseases. The drug represents an important growth driver for both the companies which are testing its use in patients with conditions like eosinophilic esophagitis as well as food and environmental allergies.

Mar 18, 2019

The 8th International Symposium On The Diabetic Foot is scheduled to be conducted between May 22-25, 2019 in The Netherlands. This conference is is the largest and most prestigious meeting devoted to lower extremity problems in diabetes.

Clinical Research

Mar 18, 2019

A Randomized Clinical Trial of 314 participants is being conducted in Blokhin's Russian Cancer Research Center to assess whether the combination of paclitaxel, capecitabine, mitomycin and intensity-modulated radiotherapy is more effective than the standard combination of capecitabine, mitomycin and intensity-modulated radiotherapy in patients with squamous-cell anal cancer.

Mar 18, 2019

A case-control Observational Study of 7000 participants is being conducted to assess if there is a need for preparative fasting prior to contrast-enhanced computed tomography. The primary outcome of the study includes rates of aspiration pneumonitis after contrast-enhanced CT scans. 

Mar 18, 2019

An Observational study of 100 patients is being conducted to determine the indications and diagnostic efficiency of whole genome sequencing in pediatric age group. The children under study are the ones with unexplained intellectual disability/developmental delay, multiple congenital abnormalities and other rare and undiagnosed diseases. 

Mar 18, 2019

An ongoing study wishes to evaluate  the effect and safety of drug eluting balloon combined for treatment of unstable angina. A total of 60 participants are included in this study and the primary end points of this study are late lumen loss (LLL) and the secondary endpoints were target lesion revascularization (TLR),and the major adverse cardiovascular events (MACE) .

Mar 18, 2019

A Study at Brigham and Women's Hospital is being conducted in 100 participants, to investigate the physiology and progression of autonomous aldosterone secretion. The primary outcome will be to evaluate the longitudinal change in plasma renin activity.

Mar 14, 2019

This is an observational study to define a set of differentially regulated secreted proteins in human cancer cells across all stages of cancer progression and correlate the results of the RT-PCR panel to the biological behavior of the tumor. They are going to Identify a set of 32 genes (including housekeeping genes) that encode for secreted proteins that correlate with disease progression using a bioinformatics approach & design probe sets for RT-PCR and run a pilot study both on FFPE and fresh tissue.

Mar 14, 2019

This is an interventional, single-armed study is to determine whether Auditory Brainstem Implant (ABI) can improve hearing in persons who are deaf in both ears, do not have Neurofibromatosis Type 2 (NF2), and are not candidates for cochlear implants. This study is sponsored and led by Dr. Daniel Lee.

Publications

Mar 14, 2019

The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society, and publishes original research reports, reviews, letters, and news covering every topic of scientific and clinical relevance to the peripheral nervous system. Articles are expertly peer-reviewed and edited.

Mar 14, 2019

Investigative Ophthalmology & Visual Science (IOVS), published online several times a month, is an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders. Included are original contributions that emphasize clinical and laboratory hypothesis-based research with statistically valid results that clearly advance the fields of ophthalmic and vision research. IOVS de-emphasizes purely descriptive research. Subjects cover the 13 sections represented by ARVO's membership and the 3 ARVO cross-sectional groups. Short updates on notable new developments in important research areas are also published, but only by invitation. Summaries of meetings/symposia and general review articles are not considered.

Mar 14, 2019

Contraception has an open access mirror journal Contraception: X, sharing the same aims and scope, editorial team, submission system, and rigorous peer review. The journal Contraception wishes to advance reproductive health through the rapid publication of the best and most interesting new scholarship regarding contraception and related fields such as abortion. The journal welcomes manuscripts from investigators working in the laboratory, clinical and social sciences, as well as public health and health professions education. 
 

Mar 14, 2019

JAIDS: Journal of Acquired Immune Deficiency Syndromes seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment, and prevention of HIV infection worldwide.

JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention.  Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.
 

Mar 14, 2019

The Journal of Hospital Medicine is the premier publication for the dissemination of research and education for the specialty of hospital medicine. The Journal of Hospital Medicine advances excellence in hospital medicine as a defined specialty through the dissemination of research, evidence-based clinical care, and advocacy of safe, effective care for hospitalized patients. 

Mar 13, 2019

Pediatric Blood Cancer is a monthly journal contains the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology etc.This months issue consists of articles on neuroblastoma, autoimmune Anemias, Sideroblastic Anemias and their association with mitochondrial disorders and much more. 

Mar 13, 2019

The Canadian Journal of Cardiology is the official journal of the Canadian Cardiovascular Society (CCS). It publishes original reports of clinical and basic research relevant to cardiovascular medicine, as well as editorials, review articles, and case reports. Papers on health outcomes, policy research, ethics, medical history, and political issues etc. This months issue consists of articles on Cardiac Rehabilitation, Noninvasive Cardiovascular Imaging, CAD in HIV etc. 

Videos

Mar 18, 2019

Surgery to remove retained products of conception is one of the most common gynecologic operations performed worldwide. Pelvic infection is a serious potential consequence of such surgery, particularly in low-income countries.

Mar 18, 2019

Watch Dr. Pedro Vieira, et al from Colorectal surgery- Digestive department, Champalimaud Foundation, Lisbon discuss and demonstrate the Standardized approach in Robotic Abdominoperineal resection. The video shows the authors' approach for abdominoperineal resection for rectal cancer using a robotic platform for assistance.

Mar 18, 2019

Watch Dr. Pedro Vieira, et al from Colorectal surgery- Digestive department, Champalimaud Foundation, Lisbon discuss and demonstrate the Standardized approach in Robotic Abdominoperineal resection. The video shows the authors' approach for abdominoperineal resection for rectal cancer using a robotic platform for assistance.

Mar 18, 2019

 

Dr. Byron L. Lam discusses new breakthroughs in gene therapy and leading-edge strategies for treating inherited blinding conditions.

Case Studies

Mar 18, 2019

A 70-year-old Japanese woman who had undergone resection for a thymic cyst 10 years earlier was found to have a solid nodule with a multilocular lesion at the site of the previous operation. We suspected that the tumor was a malignant tumor and performed trans-sternal radical thymectomy and diagnosed the lesion as micronodular thymoma with lymphoid stroma pathologically. When we reassessed the thymic cyst that had been resected 10 years earlier, a few lesions of micronodular thymoma with lymphoid stroma were found in the cyst wall. Based on these findings, we concluded that only the cystic component of micronodular thymoma with lymphoid stroma had been removed and that the residual lesion grew locally over the next 10 years before being completely resected by reoperation.

Mar 18, 2019

A 33-year-old primigravida, who was 38 weeks pregnant, presented with spontaneous severe left-sided epistaxis. Her blood pressure was into normal ranges. Clotting disorders and nasal lesions were excluded. The patient clinical worsening, due to severe anemia, and the failure of conservative treatment have imposed an emergency cesarean section, with an immediate resolution of the nasal bleeding. Treatment of severe epistaxis must always consider conservative measures first-line with early recourse to an otolaryngologist. In general, delivery of the fetus is considered curative.

Mar 18, 2019

This is the case of a 26-year-old Thai woman with a chronic intraorbital foreign body located within her medial intraconal space. The chronic intraorbital foreign body was successfully removed by endoscopic transnasal surgery, combined with assistance from a navigation system, 8 months after injury without any damage to her eye or disturbance in vision.

Mar 18, 2019

This is the case of a 26-year-old Thai woman with a chronic intraorbital foreign body located within her medial intraconal space. The chronic intraorbital foreign body was successfully removed by endoscopic transnasal surgery, combined with assistance from a navigation system, 8 months after injury without any damage to her eye or disturbance in vision.