News

Jun 01, 2020

Androgen-deprivation therapy (ADT) with an oral gonadotropin-releasing hormone (GnRH) antagonist rapidly suppressed testosterone and cut the incidence of serious heart events compared to an injectable form of ADT, a phase III trial found.

Jun 01, 2020

Some women with gestational trophoblastic tumors (GTT), a rare type of cancer that develops in the placenta during pregnancy, respond to immunotherapy when they are resistant to single chemotherapy, French researchers report. The finding comes from the TROPHIMMUN phase 2 trial with the anti-programmed death-ligand 1 (PD-L1) drug avelumab (Bavencio, Merck/Pfizer). The study will be presented at the plenary session of the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting, held virtually because of the pandemic. A glimpse of the results was given at a pre-meeting press cast by lead author Benoit You, MD, Ph.D., Lyon Investigational Center for Treatments in Oncology and Hematology, France.

Jun 01, 2020

For men with advanced prostate cancer, the oral gonadotropin-releasing hormone (GnRH) antagonist relugolix maintains testosterone suppression compared with the GnRH agonist leuprolide, while enzalutamide is associated with improved survival versus placebo in nonmetastatic, castration-resistant prostate cancer, according to two studies published online May 29 in the New England Journal of Medicine to coincide with the American Society of Clinical Oncology Virtual Scientific Program. Neal D. Shore, M.D. et al randomly assigned patients with advanced prostate cancer to receive relugolix (orally once daily) or leuprolide (injections every three months) for 48 weeks (622 and 308 patients, respectively). The researchers found that 96.7 and 88.8 percent of men receiving relugolix or leuprolide, respectively, maintained castration (sustained testosterone suppression to castrate levels) through 48 weeks. The difference indicated the noninferiority and superiority of relugolix. The superiority of relugolix over leuprolide was also demonstrated in all other key secondary endpoints.

Journal Abstracts

Jun 02, 2020

Junjie Li et.al. conducted a study to assess the efficacy and safety of the addition of capecitabine into the triple-negative breast cancer adjuvant treatment regimen was evaluated. The researchers concluded that capecitabine when added to 3 cycles of docetaxel followed by 3 cycles of a 3-drug anthracycline combination containing capecitabine instead of fluorouracil significantly improved DFS in triple-negative breast cancer  without new safety concerns.

Jun 02, 2020

Benjin D. Facer et.al. conducted a study to assess the efficacy of Intraoperative radiation therapy using electronic brachytherapy. The researchers concluded that Intraoperative radiation therapy is a convenient and well-tolerated treatment option for the appropriately selected woman undergoing partial breast irradiation. Rates of seroma formation are similar to rates reported for multiple fraction catheter-based systems.

Jun 02, 2020

William H. Smith et.al. conducted a study to assess the safety of nivolumab as Nivolumab has been demonstrated to be effective for the treatment of unresectable hepatocellular carcinoma. The researchers concluded that Combination radiation therapyand nivolumab is generally safe in the management of unresectable hepatocellular carcinoma with a low rate of serious adverse events. Prospective trials investigating the efficacy of combination nivolumab and radiation therapy are warranted.

Recent Articles

Jun 02, 2020

Benjin D. Facer et.al. conducted a study to assess the efficacy of Intraoperative radiation therapy using electronic brachytherapy. The researchers concluded that Intraoperative radiation therapy is a convenient and well-tolerated treatment option for the appropriately selected woman undergoing partial breast irradiation. Rates of seroma formation are similar to rates reported for multiple fraction catheter-based systems.

Jun 02, 2020

William H. Smith et.al. conducted a study to assess the safety of nivolumab as Nivolumab has been demonstrated to be effective for the treatment of unresectable hepatocellular carcinoma. The researchers concluded that Combination radiation therapyand nivolumab is generally safe in the management of unresectable hepatocellular carcinoma with a low rate of serious adverse events. Prospective trials investigating the efficacy of combination nivolumab and radiation therapy are warranted.

Jun 02, 2020

Suguru Uemura et.al. conducted a study to review the clinical records of the patients diagnosed with osteosarcoma at our institute between 2004 and 2018 who received high-dose chemotherapy followed by autologous stem cell transplantation. The researchers concluded that High-dose chemotherapy followed by autologous stem cell transplantation might be effective for poor responders in osteosarcoma.

Clinical Research

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Jan 31, 2020

This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.

Jan 31, 2020

This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877.

Publications

Jun 01, 2020

Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.

Jan 29, 2020

This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.

Jan 29, 2020

Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes. 

Jan 29, 2020

Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.

Jan 29, 2020

Hepatobiliary Surgery and Nutrition focuses on new findings in hepatopancreatobiliary disease and nutrition, and to provide current and practical information on diagnosis, prevention and clinical investigations. Specific areas of interest include, but not limited to, surgical techniques, clinical and basic researches, transplantation and other therapies, NASH, NAFLD, targeted drug, gut microbiota, metabolism, cancer immunity, genomics, nutrition and dietetics, etc.

Jan 29, 2020

 

Applied Radiology publishes recent researchers, articles, abstracts, dialogues and discussions on Radiology. The articles are based on current concepts, studies as well as new breakthroughs in technology. Applied Radiology welcomes clinical review articles and radiological cases for publication.

Jan 28, 2020

This book offers a comprehensive overview of all major pathologic conditions involving the lung and mediastinum and the related diagnostic procedures. Oncologic and non-oncologic conditions are reviewed and described in detail, featuring, besides normal anatomy, also high-quality images from several modalities (including X-ray, CT, MR, and PET), as well as b/w and color illustrations and line drawings. Complications associated with surgical and oncological treatments are also presented in detail with extensive imaging examples.

Videos

Jun 01, 2020

Rimma Shaposhnikov, MD UCLA gastroenterologist and Natalie Manitius, MPH, RDN, UCLA GI Dietitian, discuss which screening modalities work for colon cancer, how often one needs to get screened when a person can stop colonoscopies and dietary tips to prevent colon cancer.

May 27, 2020

Dr. Gonzalo Sapisochin presents his research using living liver transplantation as a treatment for patients with colorectal cancer that has spread to the liver. Liver transplantation is frequently used as a curative treatment for selected patients with the most common liver cancer, hepatocellular carcinoma. Dr. Sapisochin’s study is expanding liver transplantation to patients with colorectal cancer which has spread to the liver. Colorectal cancer is diagnosed in 1.8 million people every year and it is estimated that in approximately 50 percent of these cases, cancer will spread to the liver. "We think that pre-transplant chemotherapy, careful monitoring of tumors, and living donation will give our patients better results," says Dr. Sapisochin.

Jan 30, 2020

Kamal Bhsual  presented a talk on Primary Hyperparathyroidism with an objective of understanding the etiology, pathophysiology, manifestations, investigations and the management. The speaker has also discussed about the cases of Normocalcemic Primary Hyperparathyroidism and the points to consider under such instances. 

Jan 30, 2020

Dr. Patrick Kamath presented a talk on liver in cases of Cardiac diseases. The speaker has discussed in detail about its symptomatolgy, progression of symptoms, identification of diagnostic signs, recommended investigations and lastly current updates in the treatment strategies of the same. 

Case Studies

Feb 26, 2020

Isabella Aquila et.al. describe a case of Sudden death due to Takayasu’s arteritis and how histopathology came in handy by revealing eosinophilia in the aortic wall, consistent with a vasculitis such as Takayasu’s arteritis as the autopsy only showed sclerosis of the thoracic aorta, abdominal aorta and coronary arteries. 

Feb 25, 2020

Shuquan Zhao et.al. presented a case of a a 21-year-old woman diagnosed with “acute gastroenteritis”  who expired 4 days later. Autopsy findings revealed an inflammatory polypous embolic located at 1.0 cm from the left anterior descending branch. To find the real cause of this embolus, virus detection was performed through RT-PCR, however the findings were negative. 

Feb 24, 2020

During a craniotomy, hemostatic materials such as oxidized cellulose and cotton pads, commonly used to control bleeding, may cause a granulomatous reaction that may produce space-occupying mass lesions termed textiloma (or gossypiboma). Nicola Montemurro et al presents the case of a 46-year-old female who underwent a right frontotemporal craniotomy and surgical removal of an intraparenchymal cerebral hemorrhage. The patient developed a textiloma during the postoperative period that led to seizures.

Feb 24, 2020

Follicular lymphoma is an indolent non-Hodgkin lymphoma that is most prevalent among the elderly population. An 82-year-old female with refractory follicular lymphoma achieved a partial response with idelalisib treatment, Despite experiencing two incidences of the psoriasis-like rash during the treatment the patient was able to restart treatment successfully and maintain a continued partial response.