News

Jan 18, 2020

Fewer than half of clinical trial sponsors reported their results to a U.S. government registry within a year of the trial’s completion, flouting U.S. law and risking fines, British researchers reported. In a study they found that in spite of legal efforts to curb well-documented lapses in reporting of negative trial results, many sponsors are still not reporting their findings, potentially keeping patients and doctors in the dark about benefits and side effects of treatments.

Jan 17, 2020

Researchers found that a human fetal microbiome DNA signature is present in the lungs as early as the first trimester. This fetal lung microbiome showed changes in diversity during fetal development, suggesting microbiome maturation with advancing gestational age. Finally, a placental microbiome was also present in human fetal tissue, and this microbiome signature showed some taxonomic overlap with the corresponding human fetal lung microbiome.

Jan 17, 2020

Young children with mild apnea who have their tonsils removed may sleep a little better than kids who don’t get tonsillectomies, but a new study suggests surgery won’t improve cognitive function. Researchers randomly assigned 190 children 3 to 5 years old with mild apnea to either undergo adenotonsillectomy - surgery to remove both the tonsils and adenoids – or to join a waiting list for these operations and continue with routine nonsurgical care.

Journal Abstracts

Jan 21, 2020

The anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin was evaluated. β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. 

Jan 21, 2020

Researchers tried to determine whether family-focused therapy (FFT) for high-risk youths is more effective than standard psychoeducation in hastening recovery and delaying emergence of mood episodes during the 1 to 4 years after an active period of mood symptoms.  Family skills-training for youths at high risk for bipolar disorder was found to be associated with longer times between mood episodes.

Jan 21, 2020

This study analyzed the association between proportion and volume and clinical outcomes after high-risk geriatric surgery. Treatment of geriatric patients at hospitals with the highest proportion of high-risk geriatric surgery, or the most experience, was associated with improved outcomes.

Recent Articles

Jan 21, 2020

This heavily revised second edition provides a practical guide to the treatment of a range of common knee pathologies, using tried and tested solutions from the Lyon School of Knee Surgery. Extensively revised chapters focus on equipping the reader with a solid foundation in the areas of sports, degenerative and patellofemoral surgery. New chapters cover robotic arthroplasty and strategies in total knee arthroplasty, along with a collection of more unusual cases, enabling the reader to develop their confidence in dealing with a range of clinical scenarios.

Jan 21, 2020

Join outdoor-minded clinicians from all specialties for the largest & longest-running conference on Wilderness Medicine at the Big Sky Resort from February 22, 2020, to February 26, 2020.

Jan 21, 2020

The anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles functionalized with fluoride or with fluoride plus stannous on enamel and dentin was evaluated. β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to the fluoride solution on dentin. 

Clinical Research

Jan 20, 2020

Seoul National University Hospital is conducting an Interventional trial in 5750 participants in order to  investigate the efficacy and safety of prophylactic central lymph node dissection in papillary thyroid carcinoma. Primary outcome is the structural recurrence rate. Secondary outcomes are operative time, postoperative complications, and quality of life.

Jan 20, 2020

Sociedad Espanola de Gastroenterologia et.al. is conducting an Observational in 500 participants in order to create a Registry of demographic, clinical, endoscopic and histological data at baseline.

Jan 20, 2020

Sociedad Espanola de Gastroenterologia et.al. is conducting an Observational in 500 participants in order to create a Registry of demographic, clinical, endoscopic and histological data at baseline.

Jan 20, 2020

M.D. Anderson Cancer Center is conducting an Interventional trial in 50 participants in order to understand how well dual energy computed tomography (DECT) works in imaging patients with solid organ cancer that has spread to the brain. Imaging techniques, such as DECT, may help find and diagnose tumor cells and find out how far the tumor cells have spread in the brain.

Jan 20, 2020

A multicenter, double-blind, multidose, placebo-controlled, randomized, parallel-group, phase 2 study to determine if BIIB093 reduces brain contusion expansion by hour 96 when compared to placebo.

Jan 20, 2020

Mayo Clinic is conducting a study in order to assess whether the use of simple sugars given as a daily dietary supplement can improve the health of children with congenital disorders of glycosylation. The goal of this study is to collect data from patients diagnosed with congenital disorders of glycosylation and taking a simple sugar supplement. The study team wants to expand the evidence on the beneficial effects of this treatment in clinical practice.

Jan 20, 2020

Early targeted treatment of a hemodynamically significant patent ductus arteriosus (hsPDA) during the first week of life in preterm neonates is often recommended.  Shaare Zedek Medical Center is conducting an Interventional trial in 80 participants in order to compare two alternative modes of administration when enteral acetaminophen is not an option.

Publications

Jan 21, 2020

This book provides an up-to-date and detailed overview of diagnostic and management strategies for rectal cancer. It includes chapters focusing on recent diagnostic modalities such as technical advances, the role of magnetic resonance imaging (MRI), immunology, and histopathology, as well as the latest surgical techniques for the management of rectal cancer. It also discusses the role of adjuvant, neo-adjuvant and non-operative approaches.

Jan 21, 2020

This heavily revised second edition provides a practical guide to the treatment of a range of common knee pathologies, using tried and tested solutions from the Lyon School of Knee Surgery. Extensively revised chapters focus on equipping the reader with a solid foundation in the areas of sports, degenerative and patellofemoral surgery. New chapters cover robotic arthroplasty and strategies in total knee arthroplasty, along with a collection of more unusual cases, enabling the reader to develop their confidence in dealing with a range of clinical scenarios.

Jan 21, 2020

This book provides a concise reference of the histologic and clinical findings of dermatologic conditions encountered in the inpatient setting. The text is divided into twenty chapters. Histopathologic images and corresponding clinical photographs facilitate the clinical-pathologic correlation of the conditions discussed in each chapter. Bulleted summaries for quick easy-to-read reference and diagnostic pearls are provided for each of the discussed entities. Each chapter ends with several case studies in which clinical presentation, histologic interpretation and work-up of these challenging scenarios are outlined. 

Jan 21, 2020

This heavily revised second edition provides a practical guide to the treatment of a range of common knee pathologies, using tried and tested solutions from the Lyon School of Knee Surgery. Extensively revised chapters focus on equipping the reader with a solid foundation in the areas of sports, degenerative and patellofemoral surgery. New chapters cover robotic arthroplasty and strategies in total knee arthroplasty, along with a collection of more unusual cases, enabling the reader to develop their confidence in dealing with a range of clinical scenarios.

Jan 18, 2020

This multi-faceted book provides readers with comprehensive guidance to spine pain care. This six-part reference begins with a review on the epidemiology and economic impacts that present clinical and financial challenges for spine pain care.

Jan 18, 2020

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. 

Jan 18, 2020

This volume addresses three general themes in the preoperative diagnosis of early-stage esophagus cancer starting. Beginning with detailed observations of diagnosis using Endoscopic Submucosal Dissection (ESD), subsequent sections describe the current medical treatments for various types of carcinoma and conclude with detailed explanations of difficult cases and their diagnoses. The book also includes a wealth of endoscopic and pathological figures, helping scholars understand the diagnosis and treatment visually.

Videos

Jan 18, 2020

Tammie Quest, MD Professor of Emergency Medicine Director, Emory Palliative Care Center Emory University holds a talk on "Care of the Imminently Dying Patient" at the Stanford EM Grand Rounds Jan. 2020.

Jan 17, 2020

Dr. Guze discusses digital dentistry and how it has enabled dentists to do advanced same day procedures for our dental patients. The technology allows dentists to digitally scan a tooth or teeth to help create digital impressions and this is more comfortable for the patient. Once the scan is complete a tooth can be designed while the patient is still in the chair. Within 30 minutes a crown can be created and the patient can leave the procedure the same day with a new tooth.

Jan 17, 2020

Daniel P. Petrylak, MD, discusses the recent FDA approval of the antibody drug complex enfortumab vedotin for treating refractory advanced urothelial disease in patients previously treated with immunotherapy and chemotherapy. He describes how the drug complex works to fight bladder cancer by recognizing Nectin-4, a biomarker expressed on the surface of bladder cancer cells, and delivering MMAE to cause cytotoxic activity.

Jan 17, 2020

UC Irvine's Paramjit T. Joshi, MD, talks about the decisions that impact work/life balance and some myths regarding the relationship between a mentor and a mentee.

Case Studies

Jan 20, 2020

Kenta Ikeda et al report a rare case of Campylobacter fetus meningitis and pyogenic spondylodiscitis in a healthy young woman. A 35-year-old woman without significant medical history presented with fever, headache, and low back pain. C. fetus was detected from the blood culture. Cerebrospinal fluid analysis showed bacterial meningitis 2 days after onset. Although initial magnetic resonance imaging (MRI) did not reveal abnormal findings, repeated MRI showed a low-signal-intensity lesion on T1-weighted image (T1WI) and a high-signal-intensity lesion on T2WI between the L5 and S1 vertebral bodies 11 days after onset. The mode of infection was considered to be the consumption of raw chicken meat. After antibiotic treatment with 12 g/day ampicillin following 6 g/day meropenem, she was discharged 51 days after onset. As the inflammatory signs on MRI improved, oral antibiotic therapy was discontinued 85 days after onset. Although the initial MRI showed no abnormal findings, repeat MRI should be performed for patients who have persistent low back pain and fever.

Jan 20, 2020

Konstantinos Kopsidas et al report a case of bilateral serous retinal detachment in a patient with rod-cone dystrophy caused by mutation of BEST1. This followed creatine monohydrate use as a dietary supplement. A 39-year-old male with rod-cone dystrophy and low hyperopia developed extensive bilateral exudative retinal detachment following creatine monohydrate diet supplementation. Five days after stopping creatine use, the bilateral retinal detachments resolved completely. This may indicate a causative relation of creatine supplementation to the development of serous retinal detachment in a susceptible patient with pre-existing retinal dystrophy.

Jan 20, 2020

A 42-year-old Gravida 5, Para 2-0-3-2 patient with a 22 year history of endometriosis, who had had multiple laparoscopic endometriosis resections, total abdominal hysterectomy, and an exploratory laparotomy with bilateral salpingo-oophorectomy, presented with left pelvic pain when standing, dyspareunia, and a 3.7 cm cyst on ultrasound. The patient underwent laparoscopic vessel endometriosis resection and excision of endometriotic nodules from external iliac vessels. Final pathology report showed evidence of old endometriosis in all locations. On interval follow-up, the patient reported sustained relief from pain.

Jan 20, 2020

A 28-year-old Hispanic American woman presented to the emergency room of our institution with a complaint of painless and sudden onset of stiffness in her upper and lower limbs. Associated weakness worse in the distal limbs was also reported. She experienced shortness of breath with minimal exertion, diaphoresis, and anxiety. Her vital signs revealed tachycardia without corresponding fever. She was conscious, oriented, and alert. Her physical exam revealed dry mucous membranes and warm extremities. She denied recent consumption of a large carbohydrate meal, diarrhea, vomiting, use of laxatives, and use of alcohol or recreational drugs. She vaguely described two previous similar episodes in the last 7 months that spontaneously resolved. Her medical history was significant only for hypothyroidism treated with daily levothyroxine tablets. Laboratory analysis revealed the following abnormalities: an elevated anion gap with significant lactate, hypokalemia, hypomagnesemia, elevated mean corpuscular volume, elevated mean cell hemoglobin, and elevated liver enzymes with aspartate aminotransferase/alanine aminotransferase ratio > 2. She was hydrated with balanced crystalloids, and her electrolyte deficiencies corrected. The etiology of her multiple electrolyte abnormalities was unclear because alcohol use was vehemently denied. Extensive evaluation for causes of electrolyte disorder was undertaken, which was unrevealing. On further interrogation, she admitted to recent alcohol intoxication and several episodes of vomiting before presentation. She was advised to refrain from alcohol use and discharged afterward.