News

Aug 14, 2020

The emergence of more aggressive forms of leukemia in adults prompts a need for early detection and new therapeutic approaches to achieve better clinical outcomes. In a novel step forward, researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided a greater understanding of their roles in hematological malignancies.

Aug 12, 2020

In an attempt to create new methods for cancer diagnosis and treatment, an international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain. The study, that tried to understand the processes that facilitate the formation of metastases in the brain, was published in the journal Trends in Cancer.

Aug 12, 2020

What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? It may seem too good to be true, but researchers at Pavol Jozef Šafárik University in Košice, Slovakia, have identified fluorescent molecules in urine that may allow patients with malignant melanoma to do just that.

Journal Abstracts

Aug 14, 2020

Xie et.al. conducted a study to evaluate whether this survival benefit of combination chemotherapy is present in elderly patients with metastatic pancreatic ductal adenocarcinoma. The researchers concluded that elderly patients, even those older than 75 years, with metastatic pancreatic ductal adenocarcinoma benefited from combination chemotherapy.

Aug 14, 2020

Viani et.al. conducted a study to summarize existing data and identify trends in overall survival, local control, and toxicity after re-SABR in patients with recurrence of lung cancer. The researchers concluded that Re-SABR produces satisfactory local control and overall survival rates with an acceptable rate of toxicity.

Aug 14, 2020

Aaron Chanas-Larue et.al. conducted a study to propose a potential novel treatment strategy for chronic lymphocytic leukemia, repurposing FDA-approved allergy medications in combination with the targeted therapy ibrutinib to enhance drug efficacy. The researchers concluded that three over-the-counter antihistamines, clemastine, desloratadine, and loratadine, preferentially induce cell death via lysosomal membrane permeabilization in chronic lymphocytic leukemia cells, as compared to normal lymphocytes.

Recent Articles

Aug 14, 2020

Ghanem et.al. conducted a study to  analyze the impact of the time interval between hysterectomy and initiation of adjuvant radiation treatment on overall survival among women with early stage endometrial carcinoma using the National Cancer Database. The researchers concluded that time interval between hysterectomy and initiation of adjuvant radiation treatment was not an independent predictor of overall survival in women with early stage endometrial carcinoma.

Aug 14, 2020

Viani et.al. conducted a study to summarize existing data and identify trends in overall survival, local control, and toxicity after re-SABR in patients with recurrence of lung cancer. The researchers concluded that Re-SABR produces satisfactory local control and overall survival rates with an acceptable rate of toxicity.

Aug 14, 2020

Aaron Chanas-Larue et.al. conducted a study to propose a potential novel treatment strategy for chronic lymphocytic leukemia, repurposing FDA-approved allergy medications in combination with the targeted therapy ibrutinib to enhance drug efficacy. The researchers concluded that three over-the-counter antihistamines, clemastine, desloratadine, and loratadine, preferentially induce cell death via lysosomal membrane permeabilization in chronic lymphocytic leukemia cells, as compared to normal lymphocytes.

Clinical Research

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Jan 31, 2020

This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.

Jan 31, 2020

This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877.

Publications

Jun 26, 2020

In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.

Jun 04, 2020

Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded  identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer. 

Jun 01, 2020

Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.

Jan 29, 2020

 

Applied Radiology publishes recent researchers, articles, abstracts, dialogues and discussions on Radiology. The articles are based on current concepts, studies as well as new breakthroughs in technology. Applied Radiology welcomes clinical review articles and radiological cases for publication.

Jan 29, 2020

This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.

Jan 29, 2020

Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes. 

Jan 29, 2020

Journal of Diabetes Investigation is the core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes. The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. The Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology.

Videos

Jul 17, 2020

As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.

 

Jul 10, 2020

Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
 

Jul 03, 2020

 

This is a recording of the American Lung Association’s Lung Cancer Precision Medicine Summit which took place on June 18, 2020. Oncologists Dr. Erin Schenk and Dr. Ibiayi Dagogo-Jack discuss which precision medicine treatment is available for lung cancer patients and promising new research. Carly Ornstein, National Director of Lung Cancer Education, gives a high-level overview of precision medicine and discusses new resources.

Jul 03, 2020

Dr. Pasi Janne, Director of Dana-Farber Cancer Institute’s Lowe Center for Thoracic Oncology and Belfer Center for Applied Cancer Science, and colleagues discuss how COVID-19 is changing the screening, management, and treatment of thoracic cancer, including:

  • The impact on lung cancer screening
  • The role of telemedicine in caring for cancer patients
  • Managing clinical trials 

Case Studies

Jun 24, 2020

Polycythemia vera is one of the myeloproliferative neoplasms that is distinguished by the uncontrolled production of blood cells and an increased red cell mass due to acquired JAK2 mutation. It has many complications and it might increase the risk of other tumors. However, it does not cause hypercalcemia and is rarely associated with parathyroid adenoma. Ahmed M. Abdalhadi and Mohamed A. Yassin report on a 64-year-old female with polycythemia vera found to have hypercalcemia due to parathyroid adenoma.

Jun 22, 2020

Durvalumab, a programmed cell death ligand 1 inhibitor, induces various immune-related adverse events (irAEs), including lung injury. However, diffuse alveolar hemorrhage (DAH) is a rare type of lung injury due to immune checkpoint inhibitors. A 76-year-old man with c-stage IIIA squamous cell carcinoma of the lung received maintenance durvalumab therapy after chemoradiotherapy. He developed dyspnea and malaise after 11 cycles of durvalumab. Chest computed tomography showed rapidly spreading bilateral ground-glass opacity in the lungs. We diagnosed DAH by hemosiderin-laden macrophages in bloody bronchoalveolar lavage fluid. Despite mechanical ventilation, steroids, and cyclophosphamide, he died of respiratory failure. The autopsy revealed that fresh and old bleeding areas coexisted, and neither pulmonary vasculitis nor diffuse alveolar damage was detected microscopically. Furthermore, CD3+ and CD8+ lymphocytes were observed in the lung interstitium, whereas CD20+ and CD4+ lymphocytes were scarcely detected. We report the first case of durvalumab-induced DAH. We should be alert to irAEs with DAH as a potential differential diagnosis of lung injury during durvalumab treatment.

Jun 19, 2020

Only three cases of patients suffering from a localized chronic form of Langerhans cell histiocytosis (LCH) successfully treated with radiofrequency ablation (RFA) have been published so far. This is the first case report of a patient with a localized chronic form of LCH of the femur, which was successfully treated with percutaneous image-guided RFA, and who was evaluated pre-RFA and followed up post-RFA for a period of 48 months, in order to validate the safety and efficacy of this method and to obtain imaging studies depicting the actual in situ changes taking place post-RFA. RFA was proved to be a safe and efficient method when treating patients with a localized chronic form of LCH.

Jun 19, 2020

Recent data suggest that BRCA mutation carriers younger than 40 may not benefit from mammography in addition to MRI. Our objective was to evaluate screening modalities utilized in a high-risk population. Clinicopathologic data were abstracted for patients followed in a high-risk clinic from 2007 to 2017.  Three patients were diagnosed younger than 40, 1 on a mammogram, and 2 on MRI. The patient diagnosed on mammogram had no prior MRI and the lesion was seen on follow-up MRI. Interval screening MRI identified DCIS in BRCA patients with a previous normal mammogram and cancers diagnosed on mammograms were all identified on follow-up MRI. These findings support further evaluation of MRI alone until age 40 in BRCA mutation carriers.