News

Sep 24, 2020

A CDC official said today that States have begun preparing to distribute a COVID-19 vaccine if one is approved. "Every jurisdiction is heavily involved right now in their plan development," CDC official Janell Routh, MD, told the Advisory Committee on Immunization Practices during its September 22 meeting. "It was really impressive to me that even though the playbook only went out last week, states and jurisdictions have been thinking about this for quite some time."

Sep 24, 2020

A study was published online September 14 states shows light therapy statistically significantly altered multiple diffusion tensor parameters in the late subacute stage. The trial provides evidence that light therapy engages the neural substrates that affect the pathophysiologic factors associated with moderate traumatic brain injury.  Animal studies have shown that functional recovery from Traumatic Brain Injury is improved with low-level light therapy. In one such investigation, mice that were treated with low-level light therapy for 4 hours after Traumatic Brain Injury had a better functional outcome than mice that were exposed to a sham treatment.

Sep 23, 2020

A recent study suggests that patients aged 75 and older who undergo cancer surgery have lower 90-day postoperative mortality when they receive geriatric co-management than when they don't. Researchers examined data on 1,892 patients 75 and older who had elective surgery with at least a one-day hospital stay at Memorial Sloan Kettering Cancer Center in New York City, including 1,020 patients who received geriatric co-management.

Journal Abstracts

Sep 24, 2020

Alexis Cournoyer et.al. conducted a study to synthesize the evidence regarding the infection risk associated with different modalities of oxygen therapy used in treating patients with severe acute respiratory infection. The researchers concluded that the lowest flow of oxygen should be used to maintain an adequate oxygen saturation for patients with severe acute respiratory infection, and manipulation of oxygen delivery equipment should be minimized.

Sep 24, 2020

Researchers conducted this multicentre observational analysis to assess the safety profile in terms of changes in renal function after co‐treatment with sacubitril/valsartan and empagliflozin in patients with type 2 diabetes (T2D) and heart failure with reduced ejection fraction (HFrEF). The sample consisted of 108 patients with T2D and HFrEF treated with both agents: baseline sacubitril/valsartan (Group A; n = 43), baseline empagliflozin (Group B; n = 42), or both agents initiated simultaneously (Group C; n = 23). Sacubitril/valsartan and empagliflozin co-administration tend to be safe in terms of renal function in patients with HFrEF and concomitant T2D.

Sep 24, 2020

In view of a wide variation in survival of patients with stage III colon cancer according to T-N sub-stages, it appears that determination of the benefit of each therapeutic option in each T-N subgroup may yield more precise information and will assist doctors and patients in the complex shared decision-making process surrounding adjuvant therapy. From the IDEA trial, they retrieved the outcomes data of 12,834 patients with stage III colon cancer and categorized the patients in 16 sub-stages, based on T-N categories. The subgroups were noted to vary largely in 5-year DFS rate, ranging from 89% (T1N1a) to 31% (T4N2b) in the overall population. Wide variation was noted in the contribution of each therapeutic option across sub-stages. The resulting overlay bar graph indicated the absolute advantage of each treatment option. The model indicated a projected 5-year DFS of 79.6% for patients with T1N1a cancers in correlation with receiving surgery alone. A 5.6% absolute DFS gain was recorded in correlation with providing adjuvant fluoropyrimidine alone; an additional 2.3% and 0.8% gain is noted with oxaliplatin for 3 and 6 months, respectively. Patients with T4N2b cancers displayed a 13.9% 5-year DFS with surgery alone, and an 11.2%, 6.4%, 2.5% rise with the aforementioned adjuvant options, respectively.

Recent Articles

Sep 24, 2020

A study was published online September 14 states shows light therapy statistically significantly altered multiple diffusion tensor parameters in the late subacute stage. The trial provides evidence that light therapy engages the neural substrates that affect the pathophysiologic factors associated with moderate traumatic brain injury.  Animal studies have shown that functional recovery from Traumatic Brain Injury is improved with low-level light therapy. In one such investigation, mice that were treated with low-level light therapy for 4 hours after Traumatic Brain Injury had a better functional outcome than mice that were exposed to a sham treatment.

Sep 24, 2020

Alexis Cournoyer et.al. conducted a study to synthesize the evidence regarding the infection risk associated with different modalities of oxygen therapy used in treating patients with severe acute respiratory infection. The researchers concluded that the lowest flow of oxygen should be used to maintain an adequate oxygen saturation for patients with severe acute respiratory infection, and manipulation of oxygen delivery equipment should be minimized.

Sep 24, 2020

Fabienne Moret et.al. presented a case of a 52-year-old patient presented to the emergency department due to burning pain on his proximal right thigh and scrotum. Clinical examination showed an 8 × 5 cm measuring burning wound resembling lesion. During further history the patient mentioned that the day before presentation a “poppers” phial unintentionally opened in his pocket and the fluid leaked. The present case shows severe skin defects after skin-contact with alkyl nitrates in a “poppers” user.

Clinical Research

Jun 01, 2020

The purpose of this study is to find the most effective dose of radiation therapy to give to breast tumors in a shorter period of time, prior to standard partial mastectomy/axillary surgery.

Jun 01, 2020

This research study is being done to understand how patients with chronic cancer pain take their long-acting opioid medications and to develop an intervention to enhance cancer pain management.

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Feb 27, 2020

Daniel G. Whitney et.al. conducted a study to determine prevalence of major noncommunicable diseases in young adults with pediatric-onset disabilities and compared it in adults without pediatric onset disabilities. The researchers found that young adults with pediatric onset disabilities showed an early onset of several noncommunicable diseases. They were contributors to global and national burden of disease and mortality.

Feb 27, 2020

Christopher G. Brennan-Jones et.al. identified specific strategies which have shown effectiveness in reducing workplace noise. These include implementation of stricter legislation and also stress upon the need for training in the proper use of earplugs and earmuffs so as to reduce noise exposure to safe levels. 

Jan 31, 2020

This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.

Jan 31, 2020

This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877.

Publications

Jun 26, 2020

In patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), a once-daily oral regimen of ibrutinib and venetoclax was associated with deep molecular remissions in both bone marrow and peripheral blood, including in patients with high-risk disease, according to investigators in phase 2 CAPTIVATE MRD trial.

Jun 04, 2020

Georgios Tsakonas et.al. conducted a study to understand the alterations in gene expression in brain metastasis versus primary tumour as it may increase aggressiveness and impair therapeutic efforts. The researchers concluded  identified a unique gene downregulation pattern in brain metastases compared with primary tumours. This finding may explain the lower intracranial efficacy of systemic therapy, especially immunotherapy, in brain metastasis of patients with non–small-cell lung cancer. 

Jun 01, 2020

Advance in Cancer Prevention addresses all types of cancer, how cancer forms in the body, and their prevention. It focuses on Cancer Vaccines, Chemotherapy, Radioactive Iodine Therapy, Breast Reconstruction Surgery, Mammography, Chemoprevention, aromatase inhibitors, Scintimammography, Oncoplastic surgery, Sumoylation, Dietary Supplements, Cancer Screening, Cancer and Nutrition, Exercise and Cancer, Alternative Cancer Medicines, Stem cell transplants for cancer prevention, Naturopathic Treatments, Clinical Naturopathy, Cancer Prevention from nuts.

Jan 29, 2020

Hepatobiliary Surgery and Nutrition focuses on new findings in hepatopancreatobiliary disease and nutrition, and to provide current and practical information on diagnosis, prevention and clinical investigations. Specific areas of interest include, but not limited to, surgical techniques, clinical and basic researches, transplantation and other therapies, NASH, NAFLD, targeted drug, gut microbiota, metabolism, cancer immunity, genomics, nutrition and dietetics, etc.

Jan 29, 2020

 

Applied Radiology publishes recent researchers, articles, abstracts, dialogues and discussions on Radiology. The articles are based on current concepts, studies as well as new breakthroughs in technology. Applied Radiology welcomes clinical review articles and radiological cases for publication.

Jan 29, 2020

This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomised trials, observational studies and epidemiology.

Jan 29, 2020

Promoting rational therapy within the discipline of cardiology, the American Journal of Cardiovascular Drugs covers all aspects of the treatment of cardiovascular disorders, particularly the place in therapy of newer and established agents. Via a program of reviews and original clinical research articles, the journal addresses major issues relating to treatment of these disorders, including the pharmacology, efficacy and adverse effects of the major classes of drugs; information on newly developed drugs and drug classes. 

Videos

Jul 17, 2020

As many as half of patients diagnosed with metastatic HER2-positive breast cancer will see their cancer spread to their brain. Though brain metastases, or "Brain Mets," are rare, they are exceedingly difficult to treat, so these patients experience poor outcomes. At this year’s ASCO meeting, Dr. Nancy Lin of Dana-Farber Cancer Institute presented promising results from the HER2CLIMB trial for these patients. In this video BCRF talks with Dr. Lin about her research focus, Brain Mets, and HER2CLIMB’s findings.

 

Jul 10, 2020

Watch Dr. Jamie Studts discuss the quality implementation of lung cancer screening and share his thoughts on optimizing community-based implementation.
 

Jul 03, 2020

 

This is a recording of the American Lung Association’s Lung Cancer Precision Medicine Summit which took place on June 18, 2020. Oncologists Dr. Erin Schenk and Dr. Ibiayi Dagogo-Jack discuss which precision medicine treatment is available for lung cancer patients and promising new research. Carly Ornstein, National Director of Lung Cancer Education, gives a high-level overview of precision medicine and discusses new resources.

Jul 03, 2020

 

This is a recording of the American Lung Association’s Lung Cancer Precision Medicine Summit which took place on June 18, 2020. Oncologists Dr. Erin Schenk and Dr. Ibiayi Dagogo-Jack discuss which precision medicine treatment is available for lung cancer patients and promising new research. Carly Ornstein, National Director of Lung Cancer Education, gives a high-level overview of precision medicine and discusses new resources.

Case Studies

Sep 24, 2020

Fabienne Moret et.al. presented a case of a 52-year-old patient presented to the emergency department due to burning pain on his proximal right thigh and scrotum. Clinical examination showed an 8 × 5 cm measuring burning wound resembling lesion. During further history the patient mentioned that the day before presentation a “poppers” phial unintentionally opened in his pocket and the fluid leaked. The present case shows severe skin defects after skin-contact with alkyl nitrates in a “poppers” user.

Sep 23, 2020

Takeshi Ueda et.al. presented a case in which conservative treatment was achieved for an 83-year-old male patient with spontaneous pneumoperitoneum that probably occurred due to duodenal diverticulosis. He had stable vital signs and slight epigastric discomfort without any other signs of peritonitis. His medical course was uneventful, and pneumoperitoneum disappeared after 6 months.

Sep 22, 2020

A renogastric fistula is a rare complication defined by abnormal communication between the kidney and the stomach. Yassine Mellagui et.al. presented a case of a a patient admitted to the intensive care unit for hemorrhagic shock following upper gastrointestinal bleeding whose radiological investigations revealed a fistulated renal hematoma in the stomach.

Sep 21, 2020

Carlo Maiorana et.al. present a case of a  67-year-old female patient who presented with the chief complaint of tooth mobility, pain while chewing, masticatory limitations, and unsatisfying aesthetic appearance. This case describes the full-mouth rehabilitation of a partially edentulous patient seeking for a fixed rehabilitation adopting a multidisciplinary approach involving the oral surgeon, the orthodontist, and the prosthodontist.