News

Aug 19, 2019

In this study, researchers examined whether synovial fluid produced during osteoarthritis is capable of directly exciting sensory nerves supplying knee joints - those nerves responsible for transmitting pain signals. They incubated knee sensory nerves isolated from mice in either healthy or osteoarthritis synovial fluid and recorded the activity of these nerves. The team found that when incubated with osteoarthritic synovial fluid, the knee nerves were more excitable. The nerves also showed an increase in the function of TRPV1.

Aug 19, 2019

 In a move that will especially harm trans people, the LGBTQ+ community, patients who speak languages other than English, and people who need access to abortion services, the Trump administration proposed rolling back enforcement of nondiscrimination protections under the Affordable Care Act. 

Aug 19, 2019

The researchers discovered for the first time that Bcl11b, a transcription factor, determines which class of odorant receptor (OR) gene is expressed in olfactory neurons. In the absence of Bcl11b, olfactory neurons are fated to class I. But the fate can be switched to class II in the presence of Bcl11b. This also corroborates the idea that class I OR is the default OR, which undergoes a transcriptional switch in the presence of Bcl11b.

Journal Abstracts

Aug 16, 2019

The objective of this study is to investigate the role of G-protein coupled receptor 64 (GPR64) in endometrial cancer. To determine a tumor suppressor role of GPR64 in endometrial cancer, they used a siRNA loss of function approach in human endometrial adenocarcinoma cell lines. The results of this study suggest that GPR64 plays an important tumor suppressor role in endometrial cancer.

Aug 16, 2019

This is a case-matched IMPROVE study to describe the disease-associated socioeconomic burden of psoriasis in Denmark.  The IMPROVE study was a retrospective analysis of patients with a hospital diagnosis of psoriasis identified from the Danish National Patient Registry (NPR). In total, 13,025 psoriasis patients and 25,629 matched controls were identified from the NPR. In Denmark, psoriasis has a significant impact on health care costs, income, and employment, and is associated with a range of comorbidities.

Aug 16, 2019

The aim of this study was to examine demographic, site, stage, and survival factors in patients with epithelial-myoepithelial carcinoma. Epithelial-myoepithelial carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival.

Recent Articles

Aug 20, 2019

International Conference on Gerontology and Geriatric Medicine 2019 (SilverAge 2019) will create the most outstanding platform to engage in dialogue for and of older persons. SilverAge 2019 invites you to submit your research papers and case studies on or before 27th March 2019. The conference theme is "Well-being in Silver Age – from Individual to Society". However, please note that any abstract which is in line with the conference theme will be considered for review.

Aug 20, 2019

International Conference on Gerontology and Geriatric Medicine 2019 (SilverAge 2019) will create the most outstanding platform to engage in dialogue for and of older persons. SilverAge 2019 invites you to submit your research papers and case studies on or before 27th March 2019. The conference theme is "Well-being in Silver Age – from Individual to Society". However, please note that any abstract which is in line with the conference theme will be considered for review.

Aug 20, 2019

Bispecific Antibody Pipeline Congress will unite all the key opinion leaders including regulators, clinicians, and industry experts to deepen our understanding of bispecific therapeutics and exchange innovative ideas to foster meaningful research collaborations. This 3-day bispecific-focused meeting emphasizes new and unpublished insights that are not widely shared in the scientific community. Join your peers to discuss platform designs, execution strategies, and share safety data to maximize clinical performance of your candidates in an intimate setting which encourages close interactions and exchange of information.

Clinical Research

Aug 20, 2019

This is a randomized, placebo-controlled, double masked trial of the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction. Dry eye syndrome (DES) is a persistent feeling of ocular discomfort that encompasses dryness, irritation, foreign body sensation and burning. In the United States, it is the most common non-refractive cause of visits to eye care providers, and has been shown to have a significant impact on quality of life of patients who suffer from this condition. most common cause of DES is Meibomian gland disease (MGD). In the vast majority of cases, MGD is not binding, but rather causes persistant ocular discomfort. Oral antibiotics, particularly the tetracyclines and macrolides, are frequently prescribed for the treatment of MGD. There is little good-quality evidence to support this practice. This study is designed to evaluate the effectiveness of oral azithromycin on patient-reported dry eye symptoms. Concomitantly, we will also study the composition of the ocular surface microbiome in MGD, and its response for oral antibiotics.

Aug 20, 2019

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of TA-650 in patients with Behcet's disease ( BD ) with special lesions after the administration of TA-650 at a dosage of 5 mg/kg in weeks 0, 2, and 6, then every 8 weeks after week 14 up to week 46.

Aug 20, 2019

Vaccines made from a peptide may make the body build an immune response and kill tumor cells. Randomized phase I trial to study the effectiveness of vaccine therapy in treating patients who have metastatic cancer that has not responded to previous therapy.

Aug 20, 2019

Vaccines made from a peptide may make the body build an immune response and kill tumor cells. Randomized phase I trial to study the effectiveness of vaccine therapy in treating patients who have metastatic cancer that has not responded to previous therapy.

Aug 20, 2019

Patients with AGC who achieved objective response or stable disease after 2-6 months of first-line chemotherapy were randomly assigned to one of two groups, to receive either S-1 (40 mg for BSA<1.25 m2, 50 mg for 1.25≤BSA<1.50 m2 and 60 mg for BSA≥1.50 m2 b.i.d. on days 1-14, q3w) as maintenance therapy or observation. The treatment will continue until disease progression or unacceptable toxicity.

 

Aug 12, 2019

NYU Langone Health is conducting an Interventional Single Group Assignment trial in 10 participants in order to assess the role of therapy with Nivolumab in cases of Squamous Cell Carcinoma of the Esophagus. 

Aug 12, 2019

NYU Langone Health is conducting an Interventional Single Group Assignment trial in 10 participants in order to assess the role of therapy with Nivolumab in cases of Squamous Cell Carcinoma of the Esophagus. 

Publications

Sep 07, 2019

Objective: The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.

Topics

  • Pediatric endocrinology
  • Pediatric diabetes
  • Inherited metabolic diseases

Article formats

Original Research, Reviews, Mini Reviews, Opinion Papers, Case Report, Short Communications, Letters to the Editor (including comments on published papers), Book Reviews.

Aug 20, 2019

The 13th edition of the popular book, Current Surgical Therapy is scheduled to be released in November 2019. It is an ideal resource for written, oral, and recertifying board study, as well as an excellent reference for everyday clinical practice.

Aug 20, 2019

This upcoming publication offers state-of-the-art instruction to clinicians on how to recognize, diagnose and assist children with autism spectrum disorders, from early in life to transition to adulthood, while also exploring how to support pediatric patients by working with families.

Aug 20, 2019

Andreas Meiser summarizes the current literature on inhalation sedation of critically ill patients. To meet clinical demands, he describes the development of new devices to administer volatile anesthetics together with common ICU ventilators. Their basic principle is called anesthetic reflection.

Aug 19, 2019

The 9th edition of Practice Management for the Dental Team includes a wide range of dental office skills which are mapped to the Dental Assisting National Board (DANB) test blueprint including technology, communications, appointment setting, dental charting, business office procedures, etc.

Aug 19, 2019

Navigating Organized Urology, A Practical Guide is a book for researchers and practicing urologists and offers practical guidance for newly qualified urologists transitioning into urological practice.

Aug 14, 2019

Pediatric Transplantation is the only journal devoted to transplantation in infants, children and adolescents. The journal aims to advance science and practice of transplantation in children worldwide, by providing a forum that highlights the most recent advances in clinical and basic science related to this field.

Videos

Aug 18, 2019

Mike Zervas, CEO of Encompass Healthcare Data Solutions, shares his practice management insights for common problems faced in anesthesia practice management and how to run a streamlined, optimized and profitable practice.

Aug 16, 2019

Transvenous embolization (TE) has been increasingly applied for arteriovenous malformation (AVM) treatment. Transient cardiac standstill (TCS) has been described in cerebrovascular surgery but is uncommon for endovascular embolization. The authors present a patient with a ruptured thalamic AVM in whom both techniques were applied simultaneously. Surgery was considered, but the patient refused. Transarterial embolization was performed with an incomplete result. The deep-seated draining vein provided sole access to the AVM. A microcatheter was advanced into the draining vein. Under TCS, achieved with rapid ventricular pacing, complete AVM embolization was obtained. One-year magnetic resonance imaging and cerebral angiography demonstrated no residual AVM.

 

Aug 16, 2019

UCLA neurosurgeon Aria Fallah, MD, discusses the latest advancements associated with hemispherectomies, what the operation entails, post-operative recovery and long-term outcomes associated with this procedure.

 

Aug 16, 2019

Watch Dr. Bashar Safar, chief of colorectal surgery, describe one of the latest approaches against advanced stage rectal cancer: the 5x5 protocol. As an aggressive form of rectal cancer treatment, the 5x5 protocol delivers 5 grays (Gy) of radiation to patients for five days for a total of 25 Gy.

Case Studies

Aug 19, 2019

Postdural puncture headache is a leak of cerebrospinal fluid that lowers intracranial pressure and usually presents as a positional headache. If conservative treatments are not successful, the epidural blood patch is the gold standard of the treatment for dural puncture. The interlaminar approach is the most commonly used technique for an epidural blood patch. This case report describes a patient who was treated with a transforaminal epidural blood patch for postdural puncture headache following an acupuncture procedure on his lower back after two epidural blood patches using an interlaminar approach had failed. The patient underwent an acupuncture therapy for management of chronic low back pain due to postlaminectomy syndrome. After the procedure, the patient had a severe headache and the conservative treatment was not effective.

Aug 19, 2019

A 35-year-old male with no prior ophthalmic history presented with headaches, altered mental status, and fever of unknown origin. A lumbar puncture (LP) revealed an elevated white count with lymphocytic predominance, confirming a suspected meningitis. After an extensive work-up, he was discharged on oral acyclovir to cover for presumed aseptic meningitis. The patient initially improved, however, bilateral eye pain, redness, and photophobia 2 weeks after discharge prompted his first visit to the ophthalmology clinic. Exam at that time was consistent with bilateral anterior uveitis for which he was given topical prednisolone and cyclopentolate. In addition to the preceding work-up, quantitative immunoglobulin serology including IgG4 levels was added. At follow-up, he was found to have increased ocular inflammation with vitreitis, nerve head edema, and subclinical macular thickening. Visual acuity (VA) had decreased in both eyes. Serology titers for IgG had resulted in a significant elevation in IgG subclass 4 (IgG4). Optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) confirmed posterior retinal involvement. The patient was diagnosed with presumed bilateral panuveitis secondary to IgG4-ROD.

Aug 19, 2019

This is a case report of a 31-year-old primigravida who was diagnosed with an asymptomatic acute parvovirus B19 infection in the second trimester of pregnancy and its suspected association with an increased nuchal translucency (NT) measurement. Parvovirus B19 is a single-stranded DNA virus that is cytotoxic to erythroid progenitor cells, causing inhibition of erythropoiesis. While maternal disease is usually mild, fetal infection can result in spontaneous abortion, aplastic anemia, nonimmune fetal hydrops, and fetal demise. This fetus had an increased NT of 3.2 mm at 11 weeks' gestation with a normal male karyotype and microarray analysis on chorionic villi sampling, in addition to a normal fetal echocardiogram at 15 weeks' gestation.

Aug 19, 2019

A 36-year-old Iranian man presented to our clinic for evaluation of constitutional symptoms. His past medical history was significant for papillary thyroid carcinoma due to which he had undergone total thyroidectomy, cervical lymph node dissection, and radioactive iodine therapy 14 years ago. Six months prior to admission, he received radioactive iodine therapy due to the metastatic involvement of both lungs with papillary thyroid carcinoma in another center with consequent improvement in symptoms. Diffuse nodular lesions in both lungs, a lesion in the lower lobe of his left lung, not present 6 months ago, peritoneal carcinomatosis, and several para-aortic lymphadenopathies were detected by imaging studies.