Assessment of Vitamin D Status Among Cases with Pityriasis Alba

The Open Dermatology Journal
14 Jun, 2019 ,

The study aimed to assess the status of vitamin D for patients with pityriasis alba. 44 patient diagnosed with pityriasis alba were enrolled and the second group of 44 controls was involved in our study. Serum levels of circulating 25 (OH) D were measured. Study findings conclude none of the cases had sufficient serum level; the level ranged between 8.1-27.3 ng/ml. The patients had lower circulating vitamin D levels than controls.

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Background:
Pityriasis alba is a common benign skin disease occurring predominantly among children, often on their face. Clinically, the spots of pityriasis alba are off-white in color, round with poorly defined margins that bear scanty fine scales on it. No specific cause of pityriasis alba has been identified. In this disease, the number of melanocytes declines and melanosomes reduces within melanocytes. Vitamin D exerts its effect via the vitamin D receptor on melanocytes, if intracellular Ca2+ level decreases, this leads to high levels of reduced thioredoxin this, in turn, inhibit tyrosinase activity with the inhibition of melanin synthesis. In addition, the apoptotic activity of melanocytes reduces the active form of vitamin D.

Aim:
The study aimed to assess the status of vitamin D for patients with pityriasis alba.

Materials and Methods:
44 patient diagnosed with pityriasis alba were enrolled and the second group of 44 controls was involved in our study. Serum levels of circulating 25 (OH) D were measured.

Results:
None of the cases had sufficient serum level; the level ranged between 8.1-27.3 ng/ml. The patients had lower circulating vitamin D levels than controls.

Conclusion:
Our findings in the present study are significant, but further studies with large samples are needed to correlate the extent and severity of pityriasis alba with vitamin D deficiency.

Keywords:
Pityriasis alba, Melanocyte, Vitamin D, Serum level, Hypopigmentation, Pathogenesis.