Margaret L. Salisbury et.al. conducted a study to identify risk factors for interstitial lung abnormalities on high-resolution computed tomography scans and to determine progression toward clinical interstitial lung disease among subjects in a longitudinal cohort of self-reported unaffected first-degree relatives of patients with familial interstitial pneumonia. The researchers concluded that Rare and common environmental exposures are independent risk factors for radiologic abnormalities. In 5 years, progression of ILA occurred in most individuals with early interstitial lung abnormalities detected at enrollment.
American Journal of Respiratory and Critical Care Medicine