In a recent meta-analysis of 24 studies, Boone and a team of researchers considered 313 cases of borderline resectable pancreatic cancer that physicians treated with FOLFIRINOX. They analyzed the patients' overall survival rates. They also evaluated how frequently tumors shrank enough to be surgically removed. The team found that FOLFIRINOX prolonged patients' lives, on average, and made surgery possible in more instances.
Shenzhen Geno-Immune Medical Institute is conducting a Phase I/II clinical trial of gene transfer for treating Beta-thalassemia using a self-inactivating lentiviral vector to functionally correct the defective gene(s) in 20 participants. The objectives are to evaluate the safety and efficacy of the gene transfer clinical protocol.
Universidade Federal Fluminense is conducting an Observational study in 200 participants in order to propose cervicothoracic transcutaneous electrical nerve stimulation (TENS) as a non-pharmacological therapy to attenuate cardiac sympathetic overdrive in patients with heart failure.
Barts & The London NHS Trust is conducting an Observational study in 150 participants in order to identify new predisposition genes for endocrine tumours. The focus initially is on pituitary adenomas including growth hormone-secreting tumors (somatotrophinomas) and prolactin secreting tumours (prolactinomas), but the authors extended work to other pituitary tumour cases/families.
Alfasigma S.p.A. is conducting an Interventional study in 882 participants in order to evaluate the safety and efficacy of two different doses of a delayed release formulation of rifaximin, versus placebo, for the prevention of recurrence of acute diverticulitis and diverticular complications in patients with a recent episode of acute diverticulitis.
HaEmek Medical Center, Israel is conducting an Observational study in 7000 participants in order to to determine whether there is a need for preparative fasting prior to contrast-enhanced computed tomography (CT)/
A hair-sized probe that can measure key indicators of tissue damage deep in the lung has been developed by scientists. A team of scientists developed the probe, which comprises an optical fiber about 0.2mm in diameter that holds 19 sensors. Each sensor can measure different indicators in tissues, such as acidity and oxygen levels, which provide important information on the body's reaction to disease processes.
The 'American Academy of Pediatrics 2019 National Conference' is scheduled to be conducted between October 25-29, 2019 in New Orleans, LA. The conferrence will cover various sessions and events that focus on disaster medicine.
The results of a pilot study suggest that electrostimulation of one of the nerves connecting the brain to the body (the vagus nerve), could provide a novel treatment approach for patients with rheumatoid arthritis. In this study, a novel miniaturized neurostimulator called a MicroRegulator was implanted into 14 patients with rheumatoid arthritis who had failed on at least two biologics or targeted oral therapies with different mechanisms of action. Patients were randomized to three groups who were either placebo, stimulated once daily, or stimulated four times a day for 12 weeks. At the end of the study, the patients who received once-daily stimulation were shown to have a better response than those on four-times-daily stimulation.
The '8th World Heart Congress' is scheduled to be conducted between May 14-15, 2020 in Paris, France. The theme for this year's 'Tuning the Rhythm of Heart'. The conference provides an opportunity to meet experts and inspiring speakers.