Research Desk

Jul 16, 2019

Ashish Patel et.al. conductedba study to understand the distribution of blood pressure as well as the prevalence of hypertension and prehypertension among children and concluded that there was a very high prevalence of prehypertension and hypertension in Indore schoolchildren. 

Jul 16, 2019

Alexander Faje et.al. conducted a study to risk of hypophysitis following treatment with nivolumab or pembrolizumab and also to specify the clinical presentation and outcomes in these patient. The researchers concluded that Hypophysitis occured rarely with these medications and those patients had a distinct phenotype compared to hypophysitis after treatment. 

Jul 16, 2019

Celiac disease (CD), a systemic, immune-mediated disorder triggered by gluten in genetically susceptible individuals. Francesco et.al. conducted a review to focus on Celiac disease in order to outline the contribution of gut paracellular permeability when it comes to disease pathogenesis. based on current evidence derived from available clinical trials of larazotide acetate. 

Jul 16, 2019

Andrew M. Youssef et.al. evaluated the use of MRI for specific processes like somatotopy of changes in the somatosensory system for different pain origins and the differences in the effects of CRPS upon the somatosensory system. The researchers concluded that pediatric and adult CRPS are differentially represented and thus there is a significant difference in  child and adult pain vulnerability and resilience.

Jul 16, 2019

Woolfson et.al. conducted a study to assess  clinical course, and risk factors, prevalence of Passenger lymphocyte syndrome in children following ABO-compatible liver transplantation and concluded that Passenger lymphocyte syndrome in such children showed 14% prevalence and recipient blood group A+ receiving a donor O+ graft was a major risk factor. 

Jul 12, 2019

This systematic review and meta-analysis included 5 case-control studies, 2 cross-sectional studies, and 1 cohort study with a total of 93 601 unique participants with hidradenitis suppurativa to investigate the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). These results suggest that participants with hidradenitis suppurativa who had 2.12-fold increased odds for Crohn disease and 1.51-fold increased odds for ulcerative colitis. One cohort study found a 5.6-fold increased risk of inflammatory bowel disease in patients with hidradenitis suppurativa.

 

Jul 12, 2019

This is a randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of nintedanib in patients with ILD associated with systemic sclerosis. A total of 576 patients received at least one dose of nintedanib or placebo; 51.9% had diffuse cutaneous systemic sclerosis, and 48.4% were receiving mycophenolate at baseline. Among patients with ILD associated with systemic sclerosis, the annual rate of decline in forced vital capacity (FVC) was lower with nintedanib than with placebo; no clinical benefit of nintedanib was observed for other manifestations of systemic sclerosis.

 

Jul 12, 2019

The aim with this review is to discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary chronic rhinosinusitis (CRS): central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice were assessed.

Jul 12, 2019

The CLARITY is a phase II trial that combined ibrutinib with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). The primary endpoint was the eradication of MRD after 12 months of combined therapy. The combination of ibrutinib plus venetoclax was well tolerated in patients with relapsed or refractory CLL. There was a high rate of MRD eradication that led to the cessation of therapy in some patients.

Jul 12, 2019

In this study, the researchers aimed to determine whether the rs199772854A site mutation causes abnormal expression of the interleukin 17 receptor C (IL17RC) in Han Chinese patients with thoracic ossification of the posterior longitudinal ligament (T-OPLL) and predict the possible pathogenic mechanisms of T-OPLL. Analyses were performed to determine whether IL17RC is involved in the pathogenicity of T-OPLL. The results suggest that the IL17RC gene rs199772854A site polymorphism is a potential pathogenic mutation in T-OPLL disease, which may be associated with the occurrence of T-OPLL.