Bo‐Lin Ho et al assessed the safety and persistence of dabigatran after co-medication with statins. Participants in the study were stroke patients with nonvalvular atrial fibrillation (NVAF) who started dabigatran therapy within 3 months after a clinically evident ischemic cerebrovascular event between 2013 and 2017. A total of 652 patients followed dabigatran therapy for one year. According to findings, co-prescription with a statin was related to a lower risk of bleeding complications for secondary prevention of stroke in patients with NVAF who were taking dabigatran etexilate [a direct thrombin inhibitor that clinicians increasingly prescribe to prevent stroke in patients with NVAF].
Claudia Becker et al analyzed the risk of cataract in relation to exposure to ACE inhibitors (ACEIs) and other antihypertensive drugs between 1995 and 2015. They evaluated a number of prescriptions for ACEI and other antihypertensive drugs in detail and explored the use of single ACEI substances. A total of 206,931 cataract cases and the same number of matched controls were recognized. They concluded that the use of ACEI was not correlated with a materially modified risk of cataract as compared to non-use of ACEI.
Silvia Dellapasqua, MD et al sought to determine the endocrine activity in terms of ovarian function suppression (OFS) of degarelix (a gonadotropin-releasing hormone [GnRH] antagonist) vs triptorelin (a GnRH agonist) in premenopausal patients receiving letrozole as neoadjuvant endocrine therapy for breast cancer. Findings suggested that premenopausal women who received letrozole for neoadjuvant endocrine therapy achieved OFS more quickly. This was maintained more effectively with degarelix than with triptorelin.
Andrea Vecchiola et al investigated the association of aldosterone, renin or the plasma aldosterone/renin ratio (ARR) with metabolic disorders and inflammatory/vascular biomarkers. Findings revealed the correlation of ARR with the number of variables of MetS, BMI, SBP, DBP, potassium excreted fraction, LDL, PAI-1, microalbuminuria, and leptin. Overall, a continuum of cardiometabolic risk beyond the classic PA threshold screening was suggested. Compared to aldosterone or renin alone, ARR could serve as a more sensitive marker of obesity, MetS and endothelial damage in non-PA patients.
Davide Zattoni MD et al studied the utility of the Flemish version of the Triage Risk Screening Tool (fTRST) to assess precisely, the frailty in an emergency setting. They recorded more than twice the average length of hospital stay as long in the group with an fTRST score of 2 or greater (15.2 days) as compared to those with a score less than 2. Hence, they preferred fTRST as an effective tool to predict the postoperative course, to determine care goals, and also to plan for involvement of a dedicated geriatric care team.
This study examined early perioperative complications and subsidence following total hip arthroplasty (THA) with a short femoral stem. A retrospective review of 207 consecutive patients (247 hips) having undergone THA via the direct anterior approach produced only six perioperative complications. Cementless THA with a direct anterior approach with a short femoral stem provides a clinical and radiographic advantage while maintaining low complication rates.
In a double-blind trial, they randomly assigned adults with community-acquired bacterial pneumonia to receive omadacycline or moxifloxacin. Results suggest omadacycline was noninferior to moxifloxacin for the treatment of community-acquired bacterial pneumonia in adults.
Ziv et.al. studied the adverse events in Infants with cCMV treated with valganciclovir for a period of one year. They concluded that even though valganciclovir treatment is safe but a close monitoring of white blood cell count and hemoglobin levels is advisable. Amongst all, drug induced anemia should be a primary concern.
Hui Xi et.al. studied PubMed, EMBASE and Web of Science databases in order to assess observational studies regarding the relationship between serum potassium levels and mortality of acute myocardial infarction. They concluded that both lower and higher serum potassium levels are related with an increased risk of mortality.